Multicentric Castleman’s disease: a rare case presentation
نویسندگان
چکیده
Castleman’s disease (CD), also known as Angiofollicular lymph node hyperplasia, is a rare lymphoproliferative disorder first reported by dr. Benjamin Castleman in 1956. The estimated incidence rate 5 to 25 per million person-years. Histologically, the CD can be classified hyaline-vascular type, plasma cell type and mixed type. HHV-8-associated MCD (Multicentric CD) most commonly diagnosed HIV-infected or otherwise immunocompromised individuals. Co-occurrence of polyneuropathy, organomegaly, endocrinopathy, monoclonal skin changes POEMS syndrome. Treatment iMCD (idiopathic challenging, outcomes are poor because no uniform treatment guidelines. anti-interleukin-6 antibody Siltuximab with without corticosteroids preferred first-line therapy for iMCD.
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ژورنال
عنوان ژورنال: International Journal of Contemporary Pediatrics
سال: 2023
ISSN: ['2349-3283', '2349-3291']
DOI: https://doi.org/10.18203/2349-3291.ijcp20231507